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As a proof-of-concept experiment, primary cortical cultures were chronically treated with Nusinersen (NUS) (200 nM), an antisense oligonucleotide that modulates SMN2 splicing and is one of the currently FDA-approved drugs used as therapy for SMA [20, 57], from DIV7 to DIV15 , a period corresponding to neuronal functional maturation in vitro [54] ( Fig.7) which is characterized by significant synaptic development and maturation in cortical cultures

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Some people feel better with moderate carbs spread evenly throughout the day, while others prefer slightly lower total carbs

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This episode includes lots of basic science and specific, actionable protocols, right down to the details of what to do and when

Identifying the related factors to fatigue can benefit in recognizing potential causes and building a collaborative plan of care